Recent work from her lab has shown that daily stressors, marital discord, and a history of major depressive disorder alter obesity-related metabolic responses to high-fat meals, lowering post-meal energy expenditure and fat oxidation while heightening insulin production, changes that would promote weight gain. Current studies are extending this line of work.
Poorer physical fitness, depression, and obesity are all associated with higher levels of inflammation. One of her projects uses a typhoid vaccine as a peripheral immune stimulus to assess how physical fitness, depression, and obesity influence the magnitude and kinetics of a transient inflammatory response to the vaccine, as well as inflammation-associated behavioral changes: pain, cognitive problems, depressive symptoms, and fatigue. These questions are important because immune challenges are commonplace in daily life, and the ability to minimize inflammatory responsiveness influences the total burden that infectious challenges or tissue injury place on an individual.
Another segment of her current research focuses on the ways that mood and obesity interact to promote maladaptive responses to fast-food type meals (i.e., meals high in saturated fat), substantially boosting post-meal inflammation and triglyceride responses associated with cardiovascular risk. Breast cancer survivors are being studied because adjuvant anticancer therapies induce important short-and long-term cardiovascular side effects, and prior cancer therapies may influence with meal-related responses.
Selected Publications (out of 250+ papers and chapters)
Kiecolt-Glaser, J. K., Habash, D., Fagundes, C. P., Andridge, R. Peng, J., Malarkey, W. B., Belury, M. A. (in press). Daily stressors, past depression, and metabolic responses to high-fat meals: A novel path to obesity. Biological Psychiatry. NIHMS602815 10.1016/j.biopsych.2014.05.018
Kiecolt-Glaser JK Jaremka LJ, Andridge R, Peng J, Habash D, Fagundes CP, Glaser R, Malarkey WB, Belury MA (2015). Marital discord, past depression, and metabolic responses to high-fat meals: Interpersonal pathways to obesity. Psychoneuroendocrinology. 52: 239-250. DOI: 10.1016/j.psyneuen.2014.11.018 NIHMS646554
Kiecolt-Glaser, J. K., Bennett, J. M., Andridge, R. R., Peng, J., Shapiro, C.L., Malarkey, W. B, Emery, C.F., Layman, R., Mrozek, E. E., Glaser, R. (2014). Yoga’s impact on inflammation, mood, and fatigue in breast cancer survivors: A randomized controlled trial. Journal of Clinical Oncology, 32(10) 1040-1049. DOI: 10.1200/JCO.2013.51.8860 PMC3965259
Kiecolt-Glaser JK, Gouin JP, & Hantsoo LV (2010). Close relationships, inflammation, and health. Neuroscience and Biobehavioral Reviews. Close relationships, inflammation, and health. Neuroscience and Biobehavioral Reviews. 35, 33-38. PMC2891342
Kiecolt-Glaser JK (2010). Stress, food, and inflammation: Psychoneuroimmunology and nutrition at the cutting edge. Psychosomatic Medicine, 72, 365-369. PMC2868080
Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL, Glaser R (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62:1377-1384.
Glaser R, Kiecolt-Glaser JK (2005). Stress-induced immune dysfunction: Implications for health. Nature Reviews Immunology 5:243-251.
Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R (2003). Chronic stress and age-related increases in the proinflammatory cytokine interleukin-6. Proceedings of the National Academy of Sciences, USA 100:9090-9095. PMC166443
Kiecolt-Glaser JK, McGuire L, Robles T, Glaser R (2002). Psychoneuroimmunology: Psychological influences on immune function and health. Journal of Consulting and Clinical Psychology 70:537-547.
Kiecolt-Glaser JK, McGuire L, Robles T, Glaser R (2002). Emotions, morbidity, and mortality: New perspectives from psychoneuroimmunology. Annual Review of Psychology 53:83-107.
Kiecolt-Glaser JK, McGuire L, Robles T, Glaser, R (2002). Psychoneuroimmunology and psychosomatic medicine: Back to the future. Psychosomatic Medicine 64:15-28.
Kiecolt-Glaser JK, Newton TL (2001). Marriage and health: His and hers. Psychological Bulletin 127:472-503.