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Department Faculty

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Gary Wenk

Gary L. Wenk, a Professor of Psychology & Neuroscience & Molecular Virology, Immunology and Medical Genetics at the Ohio State University and Medical Center, is a leading authority on the consequences of chronic brain inflammation and animal models of Alzheimer's disease. He is also a member of the OSU Center for Brain and Spinal Cord Repair. He received a B.A. degree in psychology and biology from Albion College and a Ph.D. in Neurotoxicology from the University of Cincinnati. He then trained as a post-doctoral fellow in the laboratory of Drs. Peter Davies and Robert Terry at the Albert Einstein College of Medicine. He joined the faculty of the Departments of Psychology and Pathology at the Johns Hopkins University for nine years and served as a Program Director for the Neurobiology of Learning and Memory & Biological Basis of Behavior Program, Division of Behavioral and Neural Sciences, at the National Science Foundation. He joined the faculty of the University of Arizona and was a research scientist in the Division of Neural Systems, Memory & Aging for 15 years. He is a recipient of the Vernon & Virginia Furrow Excellence in Teaching Award and the Five Star Faculty Teaching Award. Professor Wenk's research is focused upon the investigation of drugs that can slow the progression of Alzheimer's disease and rescue the brain from the consequences of normal and pathological aging. He has been interviewed about his work by many magazines and radio stations, including NPR, WBZ, WJR, CBS News, & WABC, numerous local and national television programs, including CNN, and was interviewed by Lucasfilm, Ltd. and Amanada Productions for a 2-hr TV documentary on the topic of cognitive enhancers. (See Links)

Selected Publications

Gold, P.E., Cahill, L., & Wenk, G.L. (2003) The lowdown on Ginkgo biloba. Scientific American, April, 86-91. PDF
Doody, R.S., Mintzer, J.E., Sano, M., Wenk, G.L. & Grossberg, G.T. (2003) Alzheimer's disease: Emerging noncholinergic treatments. Geriatrics, (Suppl) 3-11.
Rosi, S., McGann, K., Hauss-Wegrzyniak, B. & Wenk, G.L. (2003) The influence of brain inflammation upon neuronal adenosine A2B receptors. Journal of Neurochemistry, 86:220-227. PDF
Wenk, G.L., McGann, K., Hauss-Wegrzyniak, B. & Rosi, S. (2003) The toxicity of tumor necrosis factor-a upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease. Neuroscience, 121: 719-729. PDF
Wenk, G.L. (2003) Neuropathologic changes in Alzheimer¹s Disease. Journal of Clinical Psychiatry, 64 (Suppl 9): 7-10. PDF
Rogawski, M. & Wenk, G.L. (2003) The neuropharmacological basis for Memantine in the treatment of Alzheimer's disease. CNS Drug Reviews, 9: 275-308. PDF
Wenk, G.L. (2003) Inflammation in Alzheimer's disease: its role and an opportunity for therapy. Brain Aging: International Journal, 3:16-20.
Marriott, L.K. & Wenk, G.L. (2004) Neurobiological consequences of long term estrogen therapy. Current Directions in Psychological Science, 13: 173-176. PDF
Wenk, G.L., McGann-Gramling, K. & Hauss-Wegrzyniak, B. (2004) The presence of the APPSWE mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation. Neuroscience, 125: 769-776. PDF
Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L. & Ongini, E. (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. Journal of Neurochemistry, 89: 484-493. PDF
Wrenn, C.C., Kinney, J.W., Marriott, L.K., Holmes, A., Harris, A.P., Saavedra, M.C., Starosta, G., Innerfield, C.E., Jacoby, A.S., Shine, J., Iismaa, T.P., Wenk, G.L. & Crawley, J.N. (2004) Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. European Journal of Neuroscience, 19:1384-1396.
Wenk, G.L. (2004) The role of BDNF and dopamine dysfunction in autism, In: M.L. Bauman & T.L. Kemper, (Eds.) The Neurobiology of Autism, 2nd Ed., The Johns Hopkins University Press, Baltimore, MD, pp. 362-370.
Woodruff-Pak, D.S., Ewers, M., Shiotani, T., Watabe, S., Tanaka, M. & Wenk, G.L. (2004) Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits. Neurobiology of Aging, 25: 807-816.
Rosi, S., Ramirez-Amaya, V., Hauss-Wegrzyniak, B. & Wenk, G.L. (2004) Chronic brain inflammation leads to a decline in hippocampal NMDA R1 receptors. Journal of Neuroinflammation, 1:12-18. PDF
Gasparini, L., Ongini, E. & Wenk, G.L. (2004) Non-steroidal anti-inflammatory drugs (NSAIDS) in Alzheimer's disease: old and new mechanisms of action. Journal of Neurochemistry, 91: 521-536. PDF
Mohmmad Abdul, H., Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B. & Butterfield, D.A. (2004) APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease. Neuroscience Letters, 368: 148-150. PDF
Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2005) Neuroinflammation alters selective patterns of behaviorally induced Arc expression in the hippocampus. Journal of Neuroscience, 25: 723-731. PDF
Daiello, L.A., Galvin, J.E. & Wenk, G.L. (2005) A case-based approach to management of Alzheimer's disease across the disease continuum. US Pharmacist, 30: (suppl. 2) 2-5.
Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K. & Wenk, G.L. (2005) CCR5 chemokine receptor antagonist DAPTA reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience, 134:671-676. PDF
Hasler, B.P., Cousins, J.C., Fridel, K.W., Wenk, G., & Bootzin, R.R. (2005).  Effect of sleep treatment on circadian rhythms in adolescents with a history of substance abuse. Sleep, 28: 64.
Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2006) Memantine reduces the consequences of chronic neuroinflammation and restores the hippocampal pattern of behaviorally-induced Arc expression. Neuroscience, 142:1303-1315. PDF
Wenk, G.L. (2006) Neuropathologic changes in Alzheimer’s disease: Potential targets for treatment. Journal of Clinical Psychiatry, 67:3-7. PDF
Wenk, G.L., Parson, C. & Danysz, W. (2006) Potential role of NMDA receptors as executors of neurodegeneration resulting from diverse insults – focus on memantine. Behavioral Pharmacology 17: 411-424. PDF
Marchalant, Y., Rosi, S. & Wenk, G.L. (2007) Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of Alzheimer’s disease. Neuroscience, 144:1516-1522. PDF
Wenk, G.L. (2007) Neurodegenerative diseases and memory – A treatment approach. , In: R.P. Kesner & J.L. Martinez, (Eds.) Neurobiology of Learning and Memory, 2nd Ed., p. 519-539, Elsevier.
Marriott, L.K., McGann-Gramling, K.R., Hauss-Wegrzyniak, B., Sheldahl, L.C., Dorsa, D. & Wenk, G.L. (2007) Region-dependent suppression of ERa by short-term constant, but not fluctuating, estrogen and interaction with neuroinflammation in the uterus. Endocrinology, 148:232-240. PDF
Marchalant, Y., Cerbai, F., Brothers, H. & Wenk, G.L. (2008) Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of Aging, in press.
Marriott, L.K., McGann-Gramling, K.R., Hauss-Wegrzyniak, B., Sheldahl, L.C., Shapiro, R.A.,  Dorsa, D.M. & Wenk, G.L. (2007) Long-term constant and pulsed estrogen replacement regimens differentially regulate estrogen receptor levels in the uterus and hypothalamus. Endocrine, 32:317-328. PDF
Wenk, G.L. & Marchalant, Y. (2008) Neuropharmacology. In: G.G. Berntson & J.T. Cacioppo, (Eds.) Handbook of Neuroscience for the Behavioral Sciences, John Wiley & Sons.
Wenk, G.L. (2008) Neuroanatomy of learning and memory. In: D.S. Charney, E.J. Nestler, & B.S. Bunney, (Eds.) Neurobiology of Mental Illness, 3rd Ed., Oxford University Press, New York, NY.
Hasler, B.P., Bootzin, R.R., Cousins, J.C., Fridel, K., & Wenk, G.L. (2008) The relationship between the dim light melatonin onset and sleep in adolescents with a history of sleep problems and substance abuse. Behavioral Sleep Medicine, in press.


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