Selected Publications
Gold, P.E., Cahill, L., & Wenk, G.L. (2003) The lowdown on Ginkgo biloba. Scientific American, April, 86-91.
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Doody, R.S., Mintzer, J.E., Sano, M., Wenk, G.L. & Grossberg, G.T. (2003) Alzheimer's disease: Emerging noncholinergic treatments. Geriatrics, (Suppl) 3-11.
Rosi, S., McGann, K., Hauss-Wegrzyniak, B. & Wenk, G.L. (2003) The influence of brain inflammation upon neuronal adenosine A2B receptors. Journal of Neurochemistry, 86:220-227.
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Wenk, G.L., McGann, K., Hauss-Wegrzyniak, B. & Rosi, S. (2003) The toxicity of tumor necrosis factor-a upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease. Neuroscience, 121: 719-729.
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Wenk, G.L. (2003) Neuropathologic changes in Alzheimer¹s Disease. Journal of Clinical Psychiatry, 64 (Suppl 9): 7-10.
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Rogawski, M. & Wenk, G.L. (2003) The neuropharmacological basis for Memantine in the treatment of Alzheimer's disease. CNS Drug Reviews, 9: 275-308. PDF
Wenk, G.L. (2003) Inflammation in Alzheimer's disease: its role and an opportunity for therapy. Brain Aging: International Journal, 3:16-20.
Marriott, L.K. & Wenk, G.L. (2004) Neurobiological consequences of long term estrogen therapy. Current Directions in Psychological Science, 13: 173-176. PDF
Wenk, G.L., McGann-Gramling, K. & Hauss-Wegrzyniak, B. (2004) The presence of the APPSWE mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation. Neuroscience, 125: 769-776.
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Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L. & Ongini, E. (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. Journal of Neurochemistry, 89: 484-493.
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Wrenn, C.C., Kinney, J.W., Marriott, L.K., Holmes, A., Harris, A.P., Saavedra, M.C., Starosta, G., Innerfield, C.E., Jacoby, A.S., Shine, J., Iismaa, T.P., Wenk, G.L. & Crawley, J.N. (2004) Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. European Journal of Neuroscience, 19:1384-1396.
Wenk, G.L. (2004) The role of BDNF and dopamine dysfunction in autism, In: M.L. Bauman & T.L. Kemper, (Eds.) The Neurobiology of Autism, 2nd Ed., The Johns Hopkins University Press, Baltimore, MD, pp. 362-370.
Woodruff-Pak, D.S., Ewers, M., Shiotani, T., Watabe, S., Tanaka, M. & Wenk, G.L. (2004) Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits. Neurobiology of Aging, 25: 807-816.
Rosi, S., Ramirez-Amaya, V., Hauss-Wegrzyniak, B. & Wenk, G.L. (2004) Chronic brain inflammation leads to a decline in hippocampal NMDA R1 receptors. Journal of Neuroinflammation, 1:12-18.
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Gasparini, L., Ongini, E. & Wenk, G.L. (2004) Non-steroidal anti-inflammatory drugs (NSAIDS) in Alzheimer's disease: old and new mechanisms of action. Journal of Neurochemistry, 91: 521-536.
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Mohmmad Abdul, H., Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B. & Butterfield, D.A. (2004) APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease. Neuroscience Letters, 368: 148-150.
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Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2005) Neuroinflammation alters selective patterns of behaviorally induced Arc expression in the hippocampus. Journal of Neuroscience, 25: 723-731.
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Daiello, L.A., Galvin, J.E. & Wenk, G.L. (2005) A case-based approach to management of Alzheimer's disease across the disease continuum. US Pharmacist, 30: (suppl. 2) 2-5.
Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K. & Wenk, G.L. (2005) CCR5 chemokine receptor antagonist DAPTA reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience, 134:671-676.
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Hasler, B.P., Cousins, J.C., Fridel, K.W., Wenk, G., & Bootzin, R.R. (2005). Effect of sleep treatment on circadian rhythms in adolescents with a history of substance abuse. Sleep, 28: 64.
Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2006) Memantine reduces the consequences of chronic neuroinflammation and restores the hippocampal pattern of behaviorally-induced Arc expression. Neuroscience, 142:1303-1315. PDF
Wenk, G.L. (2006) Neuropathologic changes in Alzheimer’s disease: Potential targets for treatment. Journal of Clinical Psychiatry, 67:3-7. PDF
Wenk, G.L., Parson, C. & Danysz, W. (2006) Potential role of NMDA receptors as executors of neurodegeneration resulting from diverse insults – focus on memantine. Behavioral Pharmacology 17: 411-424. PDF
Marchalant, Y., Rosi, S. & Wenk, G.L. (2007) Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of Alzheimer’s disease. Neuroscience, 144:1516-1522. PDF
Wenk, G.L. (2007) Neurodegenerative diseases and memory – A treatment approach. , In: R.P. Kesner & J.L. Martinez, (Eds.) Neurobiology of Learning and Memory, 2nd Ed., p. 519-539, Elsevier.
Marriott, L.K., McGann-Gramling, K.R., Hauss-Wegrzyniak, B., Sheldahl, L.C., Dorsa, D. & Wenk, G.L. (2007) Region-dependent suppression of ERa by short-term constant, but not fluctuating, estrogen and interaction with neuroinflammation in the uterus. Endocrinology, 148:232-240. PDF
Marchalant, Y., Cerbai, F., Brothers, H. & Wenk, G.L. (2008) Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of Aging, in press.
Marriott, L.K., McGann-Gramling, K.R., Hauss-Wegrzyniak, B., Sheldahl, L.C., Shapiro, R.A., Dorsa, D.M. & Wenk, G.L. (2007) Long-term constant and pulsed estrogen replacement regimens differentially regulate estrogen receptor levels in the uterus and hypothalamus. Endocrine,
32:317-328. PDF
Wenk, G.L. & Marchalant, Y. (2008) Neuropharmacology. In: G.G. Berntson & J.T. Cacioppo, (Eds.) Handbook of Neuroscience for the Behavioral Sciences, John Wiley & Sons.
Wenk, G.L. (2008) Neuroanatomy of learning and memory. In: D.S. Charney, E.J. Nestler, & B.S. Bunney, (Eds.) Neurobiology of Mental Illness, 3rd Ed., Oxford University Press, New York, NY.
Hasler, B.P., Bootzin, R.R., Cousins, J.C., Fridel, K., & Wenk, G.L. (2008) The relationship between the dim light melatonin onset and sleep in adolescents with a history of sleep problems and substance abuse. Behavioral Sleep Medicine, in press.